Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.52 |
| ▸ | PLG | P00747 | 4/20 | 0.52 |
| ▸ | PLAT | P00750 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404037 | 0.90 | PLAU (0.53) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7403925 | 0.87 | PLAU (0.54) | PLAUPLGPLATALDH1A1MAPT | |
| SCHEMBL6437740 | 0.86 | PLAU (0.61) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6433837 | 0.86 | PLAU (0.51) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7405965 | 0.84 | BACE1 (0.44) | PLAUPLGPLATALDH1A1POLB | |
| SCHEMBL7407412 | 0.83 | PLAU (0.49) | PLAUPLGPLATALDH1A1L3MBTL1 | |
| SCHEMBL6434806 | 0.82 | PLAU (0.54) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7500900 | 0.81 | PLAU (0.51) | PLAUPLGPLATALDH1A1L3MBTL1 | |
| SCHEMBL7403796 | 0.76 | PLAU (0.52) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL6432675 | 0.75 | PLAU (0.56) | PLAUPLGPLATALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |