Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413471 | 1.00 | APEX1 (0.32) | APEX1BLMCYP3A4TSHRTDP1 | |
| SCHEMBL6044540 | 0.80 | APEX1 (0.33) | APEX1BLM | |
| SCHEMBL8500805 | 0.66 | TSHR (0.37) | APEX1BLMCYP3A4TSHRMAPT | |
| SCHEMBL10655517 | 0.66 | — | — | |
| SCHEMBL727395 | 0.66 | TSHR (0.37) | APEX1BLMCYP3A4TSHRMAPT | |
| SCHEMBL6045233 | 0.65 | HSD17B10 (0.33) | APEX1CYP3A4TSHRTDP1MAPT | |
| SCHEMBL6045399 | 0.65 | HSD17B10 (0.33) | APEX1CYP3A4TSHRTDP1MAPT | |
| SCHEMBL9020114 | 0.65 | — | — | |
| SCHEMBL6044945 | 0.64 | CYP3A4 (0.33) | APEX1CYP3A4TSHRTDP1MAPT | |
| SCHEMBL6044863 | 0.64 | CYP3A4 (0.33) | APEX1CYP3A4TSHRTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678503-B1 | Delta-amino-gamma-hydroxy-omega-aryl alkanoic acid amides with enzyme especially renin inhibiting activities | NOVARTIS AG (CH) | 1999-09-01 | — | — | EP | claimed |