Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739175 | 1.00 | MAPK1 (0.56) | MAPK1GAACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL739176 | 1.00 | MAPK1 (0.56) | MAPK1GAACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL740483 | 0.89 | POLB (0.53) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL740482 | 0.89 | POLB (0.53) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL739798 | 0.84 | POLB (0.55) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL763386 | 0.80 | MAPK1 (0.79) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13853671 | 0.79 | POLB (0.62) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL741246 | 0.79 | POLB (0.53) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL763405 | 0.79 | POLB (0.53) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL741494 | 0.77 | KDM4E (0.65) | MAPK1CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |