SCHEMBL7405348

SCHEMBL7405348

Nc1cc(F)cc(Oc2ccccc2)c1N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
MAOA P21397 1/20 0.45
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
NLRP3 Q96P20 1/20 0.42
MAOB P27338 1/20 0.41
HTR2A P28223 1/20 0.41
SLC6A4 P31645 1/20 0.41
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
LTA4H P09960 1/20 0.39
TSHR P16473 1/20 0.39
GAA P10253 3/20 0.39
ALDH1A1 P00352 2/20 0.39
MAP2K1 Q02750 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1639869 0.79 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
SCHEMBL30561268 0.79 CYP1A2 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
SCHEMBL679994 0.79 CYP1A2 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
SCHEMBL5943918 0.77 MEN1 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
SCHEMBL21685531 0.74 KDM1A (0.52) MAOARAB9AMAOBLTA4HGAA
SCHEMBL31305020 0.72 GAA (0.52) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
SCHEMBL113777 0.72 GAA (0.52) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
SCHEMBL941303 0.72 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
SCHEMBL8030933 0.71 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9CYP2C19MAOA
Water SCHEMBL5145621 0.71 GAA (0.50) CYP1A2CYP3A4CYP2C9CYP2C19MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999026932-A1 BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS AXYS PHARMACEUTICALS, INC. (US) 1999-06-03 WO disclosed