Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | GBA1 | P04062 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981851 | 0.88 | PDE5A (0.70) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7281010 | 0.87 | PDE5A (1.00) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7437119 | 0.86 | PDE5A (0.74) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL13252155 | 0.86 | PDE5A (0.83) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7442498 | 0.85 | PDE5A (0.77) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7433013 | 0.85 | PDE5A (0.73) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7435476 | 0.85 | PDE5A (0.73) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7436146 | 0.85 | PDE5A (0.68) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7411550 | 0.85 | PDE5A (0.68) | PDE5APTGS1TBXAS1PTGS2MAPT | |
| SCHEMBL7277479 | 0.84 | PDE5A (1.00) | PDE5APTGS1TBXAS1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |
| WO-1999059584-A1 | COMBINATION OF PHENTOLAMINE AND CYCLIC GMP PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | SCHERING CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |