Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34474262 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AELANECYP2C19 | |
| SCHEMBL18428256 | 0.88 | ELANE (0.48) | SMN1; SMN2NPC1RAB9AELANE | |
| SCHEMBL30065232 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AELANECYP2C19 | |
| SCHEMBL4397158 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4397156 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL9029867 | 0.80 | ELANE (0.50) | SMN1; SMN2NPC1RAB9AELANECYP2C19 | |
| SCHEMBL12205561 | 0.80 | ELANE (0.50) | SMN1; SMN2NPC1RAB9AELANECYP2C19 | |
| SCHEMBL1934000 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AELANECYP2C19 | |
| SCHEMBL34474706 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AELANECYP2C19 | |
| SCHEMBL18428254 | 0.78 | PREP (0.48) | SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015454-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 2000-07-05 | — | — | EP | disclosed |
| WO-2000018770-A1 | PYRROLOPYRROLONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXO GROUP LIMITED (GB) | 2000-04-06 | — | — | WO | disclosed |
| EP-0973775-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1999012932-A1 | METHOD OF INHIBITING SERINE PROTEASE ENZYMES | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |
| WO-1998043975-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |