Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 14/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970409 | 0.81 | PSEN1 (0.43) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12247676 | 0.77 | PSEN1 (0.38) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12886318 | 0.73 | CYP2E1 (0.42) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12247672 | 0.73 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1616928 | 0.71 | NR2E1 (0.46) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7402126 | 0.70 | IDO1 (0.49) | — | |
| SCHEMBL27819262 | 0.69 | GAA (0.48) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL909015 | 0.69 | PSEN1 (0.43) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2790568 | 0.69 | NR2E1 (0.57) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30661672 | 0.68 | NR2E1 (0.37) | NR2E1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999026932-A1 | BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |