Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.40 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406133 | 1.00 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7402024 | 0.89 | GRIA1 (0.46) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7402019 | 0.89 | GRIA1 (0.46) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7406309 | 0.89 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7406301 | 0.89 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7370266 | 0.85 | SMN1; SMN2 (0.44) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL7374874 | 0.83 | SMN1; SMN2 (0.41) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL7406293 | 0.82 | GRIA1 (0.39) | GRIA1GRIA2GRIA3GRIA4HIF1A | |
| SCHEMBL7406314 | 0.82 | GRIA1 (0.39) | GRIA1GRIA2GRIA3GRIA4HIF1A | |
| SCHEMBL7371185 | 0.82 | GRIA1 (0.40) | GRIA1GRIA2GRIA3GRIA4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994107-A1 | 5-Arylisoxazol-4-yl-substituted 2-amino carboxylic acid compounds | H. LUNDBECK A/S (DK) | 2000-04-19 | — | — | EP | disclosed |
| EP-0726896-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012587-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-05-11 | — | — | WO | disclosed |