Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242906 | 0.82 | F2 (0.59) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5885528 | 0.82 | F2 (0.60) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3238624 | 0.81 | F2 (0.70) | F2PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL3245467 | 0.80 | F2 (0.55) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5885542 | 0.79 | F2 (0.51) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5885539 | 0.79 | F2 (0.51) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7808994 | 0.79 | F2 (0.74) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8186956 | 0.79 | F2 (0.57) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7025245 | 0.77 | F2 (0.55) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7159962 | 0.73 | F2 (0.70) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0900207-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997040024-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1997-10-30 | — | — | WO | disclosed |