Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 0.65 |
| ▸ | ACE2 | Q9BYF1 | 6/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.49 |
| ▸ | FAP | Q12884 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10459532 | 1.00 | ACE (0.65) | ACEACE2DPP4DPP8DPP9 | |
| SCHEMBL9791962 | 0.84 | ACE (0.59) | ACEACE2 | |
| SCHEMBL7468516 | 0.83 | ACE (0.59) | ACEACE2 | |
| SCHEMBL7408089 | 0.83 | ACE (0.59) | ACEACE2 | |
| SCHEMBL10847107 | 0.82 | ACE (0.72) | ACEACE2 | |
| SCHEMBL10664899 | 0.82 | ACE (0.72) | ACEACE2 | |
| SCHEMBL9791943 | 0.81 | ACE (0.56) | ACEACE2 | |
| SCHEMBL9791947 | 0.81 | ACE (0.56) | ACEACE2 | |
| SCHEMBL11119589 | 0.81 | ACE (0.68) | ACEACE2LTA4H | |
| SCHEMBL11119585 | 0.81 | ACE (0.68) | ACEACE2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5013861-A | Chemical intermediates for hypotensive agents, inhibitors of angiotensin converting enzyme | E. R. SQUIBB & SONS, INC. (US) | 1991-05-07 | — | — | US | disclosed |
| US-H725-H | Ureido amino and imino acids, compositions and methods for use | E. R. SQUIBB & SONS, INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4818757-A | HYPOTENSIVE AGENTS, ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1989-04-04 | — | — | US | disclosed |
| US-4810791-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1989-03-07 | — | — | US | disclosed |
| US-4740508-A | HYPOTENSIVE AGENTS, ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1988-04-26 | — | — | US | disclosed |
| US-4638010-A | HYPOTENSIVE, ENZYME INHIBITORS, ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1987-01-20 | — | — | US | disclosed |
| EP-0202776-A1 | Ureidoalkanoylaminocarbonyl amino and imino acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-11-26 | — | — | EP | disclosed |