Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737423 | 0.99 | PTPN1 (0.49) | PTPN1HRH3KCNH2MEN1KMT2A | |
| SCHEMBL739344 | 0.99 | PTPN1 (0.49) | PTPN1HRH3KCNH2MEN1KMT2A | |
| SCHEMBL739605 | 0.99 | PTPN1 (0.50) | PTPN1HRH3KCNH2MEN1KMT2A | |
| SCHEMBL738341 | 0.98 | PTPN1 (0.49) | PTPN1HRH3KCNH2POLBMAPT | |
| SCHEMBL738158 | 0.98 | PTPN1 (0.49) | PTPN1HRH3KCNH2POLBMAPT | |
| SCHEMBL739297 | 0.93 | PTPN1 (0.47) | PTPN1MEN1KMT2A | |
| SCHEMBL740876 | 0.92 | PTPN1 (0.47) | PTPN1MEN1KMT2A | |
| SCHEMBL739352 | 0.92 | PTPN1 (0.47) | PTPN1MEN1KMT2A | |
| SCHEMBL740385 | 0.92 | TLR9 (0.42) | PTPN1HRH3MEN1KMT2A | |
| SCHEMBL739307 | 0.91 | TLR9 (0.41) | PTPN1HRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138184-B2 | Isoxazole derivatives and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2012-03-20 | — | — | US | disclosed |
| US-8138184-B2 | Isoxazole derivatives and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2012-03-20 | — | — | US | disclosed |
| US-20090215768-A1 | ISOXAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2009-08-27 | — | — | US | disclosed |
| US-20090215768-A1 | ISOXAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215768-A1 | ISOXAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | TBXA2R, F12, PTH1R | PTPN1 1357/4885HRH3 4/4885KCNH2 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.