Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.54 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | CPA3 | P15088 | 3/20 | 0.45 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511480 | 0.80 | SLC1A3 (0.63) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| SCHEMBL883357 | 0.80 | SLC1A3 (0.63) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| (2R,3R)-2,3-Dibenzylsuccinic Acid SCHEMBL305323 | 0.79 | SLC1A3 (0.73) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| (2R,3R)-2,3-Dibenzylsuccinic Acid SCHEMBL4755513 | 0.79 | SLC1A3 (0.73) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| (2R,3R)-2,3-Dibenzylsuccinic Acid SCHEMBL7289849 | 0.79 | SLC1A3 (0.73) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| (2R,3R)-2,3-Dibenzylsuccinic Acid SCHEMBL2919214 | 0.79 | SLC1A3 (0.73) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| Hydrochloric Acid SCHEMBL23699362 | 0.79 | SLC1A1 (0.68) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| SCHEMBL21961161 | 0.79 | CYP1A2 (0.52) | SLC1A3SLC1A2SLC1A1CYP1A2NPC1 | |
| Hydrochloric Acid SCHEMBL23699363 | 0.79 | SLC1A1 (0.68) | SLC1A3SLC1A2SLC1A1CYP1A2ACE | |
| SCHEMBL5708390 | 0.78 | SLC1A3 (0.61) | SLC1A3SLC1A2SLC1A1CYP1A2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039664-A | Hypotensive agent | MERCK & CO., INC. (US) | 1991-08-13 | — | — | US | disclosed |
| US-5037807-A | Hypotensive agents; for treatment of congestive heart failure | MERCK & CO., INC. (US) | 1991-08-06 | — | — | US | disclosed |
| US-4839357-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE | MERCK & CO., INC. (US) | 1989-06-13 | — | — | US | disclosed |
| EP-0278158-A2 | Renin inhibitors containing phenylalanyl-histidine replacements | MERCK & CO. INC. (US) | 1988-08-17 | — | — | EP | disclosed |