Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | RHOA | P61586 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740946 | 1.00 | STS (0.48) | STSABL1RIN1MEN1KMT2A | |
| SCHEMBL742851 | 0.86 | STS (0.48) | STSABL1RIN1MEN1KMT2A | |
| SCHEMBL742852 | 0.86 | STS (0.48) | STSABL1RIN1MEN1KMT2A | |
| SCHEMBL17533942 | 0.84 | HDAC1 (0.62) | ABL1RIN1MEN1KMT2AALDH1A1 | |
| SCHEMBL762580 | 0.84 | HDAC1 (0.62) | ABL1RIN1MEN1KMT2AALDH1A1 | |
| SCHEMBL19378084 | 0.84 | HDAC1 (0.62) | ABL1RIN1MEN1KMT2AALDH1A1 | |
| SCHEMBL740750 | 0.84 | RHOA (0.47) | KMT2AALDH1A1RHOARAB9AHDAC1 | |
| SCHEMBL16895918 | 0.82 | USP30 (0.49) | STSABL1RIN1MEN1KMT2A | |
| SCHEMBL16791247 | 0.82 | USP30 (0.49) | STSABL1RIN1MEN1KMT2A | |
| SCHEMBL2636168 | 0.81 | STS (0.52) | STSALDH1A1MAPTUSP30PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |