Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.39 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | NEK4 | P51957 | 1/20 | 0.37 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.37 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73868 | 0.80 | PLK1 (0.49) | PLK1BRD4PLK3PLK2INSR | |
| SCHEMBL74215 | 0.76 | PLK1 (0.81) | PLK1BRD4PLK3PLK2INSR | |
| SCHEMBL74216 | 0.76 | PLK1 (0.81) | PLK1BRD4PLK3PLK2INSR | |
| SCHEMBL1120144 | 0.72 | PLK1 (0.53) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL73871 | 0.71 | PLK1 (0.91) | PLK1BRD4PLK3PLK2INSR | |
| SCHEMBL73872 | 0.71 | PLK1 (0.91) | PLK1BRD4PLK3PLK2INSR | |
| SCHEMBL6127769 | 0.71 | PLK1 (0.59) | PLK1BRD4PLK3PLK2 | |
| SCHEMBL6124280 | 0.71 | PLK1 (0.73) | PLK1BRD4PLK3PLK2INSR | |
| SCHEMBL84783 | 0.70 | PLK1 (0.82) | PLK1BRD4PLK3PLK2INSR | |
| SCHEMBL3234508 | 0.68 | PLK1 (0.82) | PLK1BRD4PLK3PLK2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129387-B2 | Substituted 5,6-dihydroimidazo[1,5-F]pteridines useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |