Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10323148 | 0.89 | GRM2 (1.00) | GRM2 | |
| SCHEMBL10325106 | 0.89 | GRM2 (1.00) | GRM2 | |
| SCHEMBL10323147 | 0.89 | GRM2 (1.00) | GRM2 | |
| SCHEMBL741461 | 0.87 | GRM2 (1.00) | GRM2 | |
| SCHEMBL743143 | 0.78 | GRM2 (1.00) | GRM2 | |
| SCHEMBL10325109 | 0.77 | GRM2 (1.00) | GRM2 | |
| SCHEMBL10325107 | 0.77 | GRM2 (1.00) | GRM2 | |
| SCHEMBL10325108 | 0.77 | GRM2 (1.00) | GRM2 | |
| SCHEMBL30795377 | 0.77 | GRM2 (1.00) | GRM2 | |
| SCHEMBL742376 | 0.77 | GRM2 (1.00) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430021-A1 | 7-ARYL-1,2,4-TRIAZOLOÝ4,3-A¨PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceuticals Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130423-A1 | 7-ARYL-1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2010-11-18 | — | — | WO | disclosed |