Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.61 |
| ▸ | MME | P08473 | 7/20 | 0.61 |
| ▸ | CPA1 | P15085 | 2/20 | 0.61 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.48 |
| ▸ | IL2 | P60568 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411428 | 1.00 | ACE (0.61) | ACEMMECPA1ACE2CA2 | |
| SCHEMBL7405095 | 0.86 | MME (0.61) | ACEMMECPA1ACE2 | |
| SCHEMBL9849034 | 0.83 | ACE (0.49) | ACEMMECA2 | |
| SCHEMBL7410807 | 0.83 | ACE (0.49) | ACEMMECA2 | |
| SCHEMBL7410810 | 0.83 | ACE (0.49) | ACEMMECA2 | |
| SCHEMBL7413039 | 0.83 | ACE (0.49) | ACEMMECA2 | |
| SCHEMBL7410802 | 0.83 | ACE (0.49) | ACEMMECA2 | |
| SCHEMBL7418383 | 0.82 | MME (0.63) | ACEMMECPA1ACE2 | |
| SCHEMBL7418391 | 0.82 | MME (0.63) | ACEMMECPA1ACE2 | |
| SCHEMBL9119415 | 0.82 | MME (0.63) | ACEMMECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5414013-A | Enzyme inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5414017-A | Cardiovascular agents | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0449523-B1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | SQUIBB & SONS INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5223516-A | Endopeptidase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| EP-0449523-A1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | E.R. SQUIBB & SONS, INC. (US) | 1991-10-02 | — | — | EP | disclosed |