Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP36 | Q9P275 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738866 | 0.91 | AURKA (0.53) | AURKAABL1BCRHDAC6CDK2 | |
| SCHEMBL741311 | 0.87 | AURKA (0.53) | USP36AURKAABL1BCRHDAC6 | |
| SCHEMBL1778008 | 0.85 | AURKA (0.49) | AURKAABL1BCR | |
| SCHEMBL740102 | 0.85 | AURKA (0.65) | AURKAABL1BCRFLT3 | |
| SCHEMBL2415778 | 0.85 | CDK2 (0.42) | AURKAABL1BCRHDAC6CDK2 | |
| SCHEMBL740292 | 0.84 | AURKA (0.55) | USP36AURKAABL1BCRHDAC6 | |
| SCHEMBL742124 | 0.84 | AURKA (0.48) | USP36AURKAABL1BCRSRC | |
| SCHEMBL741731 | 0.82 | ABL1 (0.61) | AURKAABL1BCRFLT3NPC1 | |
| SCHEMBL740581 | 0.82 | ABL1 (0.63) | AURKAABL1BCRFLT3DYRK1A | |
| SCHEMBL741356 | 0.82 | KMT2A (0.43) | AURKAABL1BCRNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |