Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407394 | 0.85 | GAA (0.46) | COMTTDP1GAASMN1; SMN2MEN1 | |
| SCHEMBL2013788 | 0.85 | COMT (0.44) | COMTTDP1GAASMN1; SMN2MEN1 | |
| SCHEMBL12468150 | 0.85 | COMT (0.44) | COMTTSHRDCTPP1TDP1GAA | |
| SCHEMBL7408672 | 0.84 | COMT (0.43) | COMTDCTPP1TDP1GAASMN1; SMN2 | |
| SCHEMBL7419544 | 0.83 | COMT (0.43) | COMTTSHRTDP1GAASMN1; SMN2 | |
| SCHEMBL12525557 | 0.83 | COMT (0.43) | COMTDCTPP1TDP1GAASMN1; SMN2 | |
| SCHEMBL7407600 | 0.82 | COMT (0.42) | COMTTDP1GAASMN1; SMN2MEN1 | |
| SCHEMBL2016162 | 0.82 | COMT (0.44) | COMTDCTPP1TDP1GAASMN1; SMN2 | |
| SCHEMBL2963423 | 0.80 | SMN1; SMN2 (0.45) | COMTTSHRTDP1GAASMN1; SMN2 | |
| SCHEMBL12566396 | 0.79 | ERN1 (0.47) | COMTDCTPP1TDP1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935511-A | Nervous system, gastrointestinal disorders | RORER PHARMACEUTICAL CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |