Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 14/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | PTAFR | P25105 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411867 | 0.83 | PDE3B (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11405323 | 0.80 | PDE3B (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11416643 | 0.80 | PDE3B (0.72) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL7315355 | 0.77 | PDE3B (0.55) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL2946966 | 0.77 | PDE3B (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11323306 | 0.75 | PDE3B (0.88) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL11573620 | 0.75 | PDE3B (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7304264 | 0.75 | PDE3B (0.54) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL10376673 | 0.74 | PDE3B (0.54) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL10658292 | 0.74 | PTPN11 (0.58) | KDM4EALDH1A1TSHRKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904667-A | 1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method for increasing the cardiac output of a mammal with them | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-02-27 | — | — | US | disclosed |
| EP-0116948-B1 | (2-OXO-1,2,3,5-TETRAHYDROIMIDAZO-(2,1-B)QUINAZOLINYL)-OXYALKYL-AMIDES | SYNTEX (U.S.A.) INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4663320-A | ANTITUMOR AGENTS, ANTICOAGULANTS | SYNTEX (U.S.A.) INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4551459-A | Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides | SYNTEX (U.S.A.) INC. (US) | 1985-11-05 | — | — | US | disclosed |
| US-4490371-A | ANTICOAGULANTS, PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0116948-A2 | (2-Oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyl-amides | SYNTEX (U.S.A.) INC. (US) | 1984-08-29 | — | — | EP | disclosed |