Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451073 | 0.76 | GRIA1 (0.60) | GRIA1GRIA3HCAR2PTPN1 | |
| SCHEMBL16571684 | 0.76 | GRIA1 (0.44) | GRIA1GRIA3HCAR2PTPN1 | |
| SCHEMBL16571889 | 0.73 | GRIA1 (0.41) | GRIA1GRIA3HCAR2PTPN1 | |
| SCHEMBL16571451 | 0.71 | GRIA1 (0.41) | GRIA1GRIA3HCAR2PTPN1 | |
| SCHEMBL18550683 | 0.70 | GRIA1 (0.40) | GRIA1GRIA3HCAR2PTPN1 | |
| SCHEMBL16571467 | 0.69 | GRIA1 (0.42) | GRIA1GRIA3HCAR2 | |
| SCHEMBL2564471 | 0.68 | PTPN1 (0.61) | PTPN1 | |
| SCHEMBL1807557 | 0.68 | GRIA1 (0.38) | GRIA1GRIA3HCAR2PTPN1 | |
| SCHEMBL4054647 | 0.67 | PTPN1 (0.41) | GRIA1GRIA3PTPN1 | |
| SCHEMBL19668565 | 0.66 | KDM4E (0.42) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6177425-B1 | STEREOSPECIFIC ENANTIOMER HAVING ANTIINFLAMMATORY AND NEUTROPHIL ELASTASE INHIBITING ACTIVITY; FOR TREATMENT OF CHRONIC BRONCHITIS IN HUMANS OR ANIMALS | GLAXO WELLCOME INC. | 2001-01-23 | — | — | US | disclosed |
| EP-1015455-A1 | PYRROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-1003748-A2 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999012934-A1 | PYRROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |
| WO-1999012933-A2 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |