Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321654 | 0.91 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7378466 | 0.89 | PDE4B (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30683833 | 0.87 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29798131 | 0.86 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7211275 | 0.86 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7795020 | 0.85 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7858781 | 0.85 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7794941 | 0.85 | PDE4B (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7786701 | 0.84 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7786788 | 0.84 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861421-A | 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-19 | — | — | US | disclosed |
| EP-0800393-A4 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-ONE MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-05-06 | — | — | EP | disclosed |
| EP-0799176-A4 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-ONE DIMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-03-25 | — | — | EP | disclosed |
| EP-0800393-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-ONE MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| EP-0799176-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-ONE DIMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019995-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-ONE MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-04 | — | — | WO | disclosed |
| WO-1996020153-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-ONE DIMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-04 | — | — | WO | disclosed |