Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | IDE | P14735 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406055 | 0.82 | CNR2 (0.51) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL4407849 | 0.82 | CNR2 (0.51) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL4409119 | 0.78 | CNR2 (0.49) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL20711367 | 0.78 | CNR2 (0.49) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL4407077 | 0.78 | CNR2 (0.49) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL25013971 | 0.77 | — | — | |
| SCHEMBL12764087 | 0.77 | CYP1A2 (0.48) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL4404533 | 0.76 | CNR2 (0.47) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL4406803 | 0.75 | MAPT (0.44) | CNR2TRPV1MAPTALDH1A1GRM2 | |
| SCHEMBL4408212 | 0.74 | CNR2 (0.46) | CNR2TRPV1MAPTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5414013-A | Enzyme inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5414017-A | Cardiovascular agents | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0449523-B1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | SQUIBB & SONS INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5223516-A | Endopeptidase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| EP-0449523-A1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | E.R. SQUIBB & SONS, INC. (US) | 1991-10-02 | — | — | EP | disclosed |