SCHEMBL7414461

SCHEMBL7414461

CCOC(=O)C(C)N(C)c1c(F)c(Oc2cccc(C3=NCCN3C)c2)nc(Oc2cc(C#N)ccc2OCc2ccccc2)c1F

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
F2 P00734 10/20 0.49
F10 P00742 8/20 0.49
PLG P00747 5/20 0.36
PLAU P00749 5/20 0.36
PLAT P00750 4/20 0.36
PTGER1 P34995 2/20 0.35
SLC6A9 P48067 1/20 0.34
F3 P13726 3/20 0.34
ICMT O60725 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8060516 0.94 F2 (0.47) F2F10PLGPLAUPLAT
SCHEMBL6591417 0.94 F2 (0.48) F2F10PLGPLAUPLAT
SCHEMBL6597090 0.94 F2 (0.48) F2F10PLGPLAUPLAT
SCHEMBL6593437 0.93 F2 (0.47) F2F10PLGPLAUPLAT
SCHEMBL6594063 0.92 F2 (0.48) F2F10PLGPLAUPLAT
SCHEMBL6590727 0.90 F10 (0.46) F2F10PLGPLAUPLAT
SCHEMBL6594847 0.90 F10 (0.49) F2F10PLGPLAUPLAT
SCHEMBL6594546 0.88 F2 (0.45) F2F10PLGPLAUPLAT
SCHEMBL6593254 0.88 F10 (0.44) F2F10PLGPLAUPLAT
SCHEMBL6592625 0.88 F10 (0.55) F2F10PLGPLAUPLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6242454-B1 Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants BERLEX LABORATORIES INC. 2001-06-05 US disclosed
US-5994375-A ANTICOAGULANTS BERLEX LABORATORIES, INC. (US) 1999-11-30 US disclosed