Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1408464 | 0.87 | HTT (0.63) | FGFR1HTT | |
| SCHEMBL1408316 | 0.85 | FGFR1 (0.66) | FGFR1HTTRIPK1RIPK3RAB9A | |
| SCHEMBL7383547 | 0.81 | FGFR1 (0.72) | FGFR1HTTPDE4APDE4BPDE4C | |
| SCHEMBL13889341 | 0.80 | HTT (0.66) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL12970574 | 0.80 | FGFR1 (0.68) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL30402227 | 0.79 | HTT (0.88) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL3419279 | 0.79 | HTT (0.88) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| Bicarbonate SCHEMBL2334509 | 0.78 | HTT (0.85) | FGFR1HTT | |
| SCHEMBL28004670 | 0.77 | HTT (0.66) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL23514707 | 0.77 | HTT (0.60) | FGFR1HTTKDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |