Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12502757 | 0.88 | KDM4E (0.51) | MAPTKDM4EALDH1A1 | |
| SCHEMBL12503041 | 0.84 | MAPT (0.51) | LMNAMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL12502545 | 0.83 | NOTUM (0.49) | LMNAMAPTKDM4EALDH1A1POLB | |
| SCHEMBL12502932 | 0.78 | NOTUM (0.55) | LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL3993455 | 0.78 | KMT2A (0.44) | LMNAFEN1MAPTTP53KDM4E | |
| SCHEMBL27938770 | 0.77 | MAPT (0.52) | MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL3494707 | 0.77 | MAPT (0.49) | LMNAMAPTTP53KDM4EKMT2A | |
| SCHEMBL12502722 | 0.76 | NOTUM (0.58) | LMNAMAPTKDM4EALDH1A1POLB | |
| SCHEMBL2265690 | 0.76 | GAA (0.47) | LMNAFEN1MAPTTP53KDM4E | |
| SCHEMBL12503112 | 0.75 | MAPT (0.48) | MAPTTP53KDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649432-B1 | FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS | ZENECA LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| US-5532366-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-07-02 | — | — | US | disclosed |
| WO-1994001455-A1 | FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1994-01-20 | — | — | WO | disclosed |