Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.51 |
| ▸ | PDE4A | P27815 | 8/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416298 | 0.94 | PDE4A (0.49) | DHPSPDE4AKAT2BPDE4BPDE4C | |
| SCHEMBL7415715 | 0.89 | PDE4A (0.53) | DHPSPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7411984 | 0.85 | BRD9 (0.46) | PDE4AKAT2BPDE4BPDE4CPDE4D | |
| SCHEMBL15815214 | 0.82 | PSMB5 (0.52) | DHPSPDE4AKAT2BPDE4BPDE4C | |
| SCHEMBL7411142 | 0.81 | PDE4A (0.64) | DHPSPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15815698 | 0.79 | BRD4 (0.54) | DHPSPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4064849 | 0.77 | PDE4A (0.47) | PDE4AKAT2BPDE4BPDE4CPDE4D | |
| SCHEMBL15815770 | 0.77 | PDE4A (0.47) | DHPSPDE4AKAT2BPDE4BPDE4C | |
| SCHEMBL15206381 | 0.74 | MEN1 (0.42) | DHPSPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7416549 | 0.74 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466697-A | 8-phenyl-1,6-naphthyridin-5-ones | SYNTEX (U.S.A.) INC. (US) | 1995-11-14 | — | — | US | disclosed |