Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493397 | 0.87 | NR1H2 (0.41) | NR1H2ESR2ADORA1MAPTUSP2 | |
| SCHEMBL626936 | 0.84 | ESR2 (0.49) | NR1H2ESR2ADORA1MAPTUSP2 | |
| SCHEMBL10774824 | 0.79 | BPTF (0.51) | MAPTKDM4ESMN1; SMN2CTSKGAA | |
| SCHEMBL9901697 | 0.78 | ADORA1 (0.46) | NR1H2ESR2ADORA1MAPTKDM4E | |
| SCHEMBL8262725 | 0.77 | ADORA1 (0.55) | NR1H2ESR2ADORA1MAPTKDM4E | |
| SCHEMBL22056067 | 0.76 | NR1H2 (0.46) | NR1H2ESR2ADORA1MAPTKDM4E | |
| SCHEMBL29516101 | 0.76 | NR1H2 (0.61) | NR1H2ESR2ADORA1MAPTKDM4E | |
| SCHEMBL24269251 | 0.75 | NR1H2 (0.51) | NR1H2ESR2ADORA1MAPTKDM4E | |
| SCHEMBL16356223 | 0.75 | NR1H2 (0.51) | NR1H2ESR2ADORA1MAPTKDM4E | |
| SCHEMBL5599594 | 0.75 | ESR2 (0.62) | NR1H2ESR2ADORA1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230225-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032632-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |