Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5704529 | 0.92 | MAPT (0.61) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL4226708 | 0.92 | CYP19A1 (0.63) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL7702894 | 0.91 | MAPT (0.60) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL29375687 | 0.91 | MAPT (0.60) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL6431028 | 0.88 | MAPT (0.59) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL1008451 | 0.87 | HTT (0.60) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL5462981 | 0.86 | TDP1 (0.60) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL8240311 | 0.86 | MAPT (0.65) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL7399378 | 0.86 | HTT (0.59) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL5099839 | 0.86 | MAPT (0.65) | CYP19A1MAPTSMN1; SMN2HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613476-A1 | 3-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010114-A1 | 3-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |