Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452104 | 0.85 | NPSR1 (0.68) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL4401833 | 0.85 | NPSR1 (0.68) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL7415050 | 0.84 | NPSR1 (0.56) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL7459195 | 0.81 | NPSR1 (0.75) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL7458560 | 0.81 | NPSR1 (0.64) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL4931496 | 0.80 | NPSR1 (0.62) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL7459881 | 0.79 | NPSR1 (0.61) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL7459875 | 0.79 | NPSR1 (0.61) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL7463997 | 0.79 | NPSR1 (0.61) | NPSR1LMNAGABRG2GABRB3GABRA5 | |
| SCHEMBL7416513 | 0.78 | NPSR1 (0.60) | NPSR1LMNAGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156787-A | Substituted thienlycyclohexanone derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |
| US-6143773-A | Substituted thienobenzisoxazole derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| WO-1995007885-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1995-03-23 | — | — | WO | disclosed |