Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.74 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | P4HB | P07237 | 2/20 | 0.43 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375509 | 0.87 | PDCD1 (0.71) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL10848993 | 0.87 | PDCD1 (0.71) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL21457292 | 0.85 | PDCD1 (1.00) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL21457289 | 0.85 | PDCD1 (1.00) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL20786827 | 0.83 | MAPT (0.51) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL20787944 | 0.83 | MAPT (0.51) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL14113061 | 0.81 | KMT2A (0.53) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL21065588 | 0.81 | KMT2A (0.53) | PDCD1CD274MAPTKMT2AALDH1A1 | |
| SCHEMBL3115027 | 0.81 | AKR1C3 (0.59) | PDCD1CD274KDM4EFBP1P4HB | |
| SCHEMBL6981746 | 0.81 | AKR1C3 (0.59) | PDCD1CD274KDM4EFBP1P4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934265-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | Du Pont Pharmaceuticals Company (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998006694-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |