Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202230 | 0.88 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4CGAK | |
| SCHEMBL8204138 | 0.86 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CGAK | |
| SCHEMBL5823060 | 0.85 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL5823358 | 0.85 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CGAK | |
| SCHEMBL8204245 | 0.84 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CGAK | |
| SCHEMBL5823404 | 0.83 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CGAK | |
| SCHEMBL7450822 | 0.83 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| Hydrochloric Acid SCHEMBL8202247 | 0.82 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7474371 | 0.82 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4CGAK | |
| SCHEMBL6925796 | 0.81 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080790-A | SELECTIVE AND POTENT INHIBITORS OF PHOSPHODIESTERASE IV AND ARE USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY DISEASES AND THE ALLEVIATION OF CONDITIONS ASSOCIATED WITH CENTRAL NERVOUS MALFUNCTION | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0618889-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1998-12-30 | — | — | EP | disclosed |
| US-5674880-A | ANTIINFLAMMATORY AGENT | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-07 | — | — | US | disclosed |
| US-5491147-A | PHOSPHODIESTERASE IV INHIBITORS | CELLTECH, LIMITED (GB) | 1996-02-13 | — | — | US | disclosed |
| EP-0618889-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-10-12 | — | — | EP | disclosed |
| WO-1994010118-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |