Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413984 | 0.87 | ATM (0.50) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7415067 | 0.87 | ATM (0.47) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7412535 | 0.84 | ATM (0.47) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7406462 | 0.83 | ATM (0.46) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7412763 | 0.83 | ATM (0.46) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7412336 | 0.83 | ATM (0.46) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7416764 | 0.83 | ATM (0.46) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7416991 | 0.83 | ELANE (0.46) | ATMELANECTSKAAK1PRTN3 | |
| SCHEMBL7413969 | 0.82 | ATM (0.45) | ATMELANECTSKAAK1CTSL | |
| SCHEMBL7413187 | 0.82 | ATM (0.45) | ATMELANECTSKAAK1PRTN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733882-A | Retroviral protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | disclosed |
| WO-1993002057-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-04 | — | — | WO | disclosed |