Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 9/20 | 0.44 |
| ▸ | ACACA | Q13085 | 5/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377073 | 0.84 | KMT2A (0.56) | KMT2ADRD2ACACBACACACTSS | |
| SCHEMBL3816616 | 0.84 | KMT2A (0.56) | KMT2ADRD2ACACBACACACTSS | |
| SCHEMBL3942686 | 0.84 | KMT2A (0.56) | KMT2ADRD2ACACBACACACTSS | |
| SCHEMBL190838 | 0.84 | KMT2A (0.56) | KMT2ADRD2ACACBACACACTSS | |
| SCHEMBL14408856 | 0.83 | KMT2A (0.45) | KMT2ADRD2ACACBACACACTSS | |
| Bicarbonate SCHEMBL1580718 | 0.81 | KMT2A (0.57) | KMT2ADRD2ACACBACACACTSS | |
| Formaldehyde SCHEMBL28082239 | 0.81 | KMT2A (0.54) | KMT2ADRD2ACACBACACACTSS | |
| SCHEMBL4815309 | 0.79 | KMT2A (0.44) | KMT2ADRD2ACACBACACACTSS | |
| SCHEMBL13683507 | 0.79 | KMT2A (0.44) | KMT2ADRD2ACACBACACACTSS | |
| SCHEMBL4815317 | 0.79 | KMT2A (0.44) | KMT2ADRD2ACACBACACACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |