Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.44 |
| ▸ | FAP | Q12884 | 2/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740469 | 0.89 | KDM4E (0.55) | GRIN2BPOLBDPP4KDM4EMEN1 | |
| SCHEMBL741429 | 0.88 | POLB (0.49) | GRIN2BPOLBKDM4EMEN1KMT2A | |
| SCHEMBL742047 | 0.87 | GRIN2B (0.57) | GRIN2BPOLBDPP4KDM4EHTR2B | |
| SCHEMBL742005 | 0.87 | GRIN2B (0.52) | GRIN2BPOLBDPP4KDM4EHTR2B | |
| SCHEMBL739171 | 0.84 | POLB (0.52) | GRIN2BPOLBDPP4KDM4EHTR2B | |
| SCHEMBL740090 | 0.84 | HTR2B (0.56) | GRIN2BPOLBKDM4EHTR2BMAPK1 | |
| SCHEMBL740091 | 0.84 | HTR2B (0.56) | GRIN2BPOLBKDM4EHTR2BMAPK1 | |
| SCHEMBL741819 | 0.84 | POLB (0.49) | GRIN2BPOLBKDM4EHTR2BMAPK1 | |
| SCHEMBL741920 | 0.84 | POLB (0.46) | GRIN2BPOLBDPP4KDM4EHTR2B | |
| SCHEMBL742573 | 0.83 | GRIN2B (0.49) | GRIN2BPOLBKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |