Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542911 | 0.84 | PDE5A (0.68) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8540438 | 0.83 | PDE5A (0.65) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7499068 | 0.79 | PDE5A (1.00) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31034788 | 0.78 | PDE5A (1.00) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13192079 | 0.78 | PDE5A (0.76) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8015683 | 0.78 | PDE5A (1.00) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31038289 | 0.78 | PDE5A (1.00) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13191863 | 0.78 | PDE5A (0.76) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2458882 | 0.78 | PDE5A (1.00) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7493988 | 0.78 | PDE5A (1.00) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691967-B1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | EISAI CO LTD (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5707998-A | CYCLIC-GMP PHOSPHODIESTERASE INHIBITORS, TREATING CARDIOVASCULAR DISORDERS AND ASTHMA | EISAI CO., LTD. (JP) | 1998-01-13 | — | — | US | disclosed |
| WO-1994022855-A1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | EISAI CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |