Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.49 |
| ▸ | PDE4A | P27815 | 9/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17895369 | 0.86 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7420849 | 0.86 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4COPRK1 | |
| SCHEMBL23792952 | 0.85 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4COPRK1 | |
| SCHEMBL27471911 | 0.85 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4COPRK1 | |
| SCHEMBL71331 | 0.84 | PDE4D (0.65) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7336558 | 0.82 | PDE4D (0.64) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7415351 | 0.82 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7420388 | 0.82 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7355954 | 0.81 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL23792967 | 0.80 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4COPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |