Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 14/20 | 0.60 |
| ▸ | DPP8 | Q6V1X1 | 11/20 | 0.60 |
| ▸ | DPP9 | Q86TI2 | 11/20 | 0.60 |
| ▸ | DPP7 | Q9UHL4 | 11/20 | 0.60 |
| ▸ | FAP | Q12884 | 9/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185307 | 1.00 | DPP4 (0.60) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7191378 | 1.00 | DPP4 (0.60) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7182285 | 0.88 | DPP4 (0.61) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7182281 | 0.88 | DPP4 (0.61) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7177515 | 0.86 | DPP4 (0.63) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7177518 | 0.86 | DPP4 (0.63) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL6171475 | 0.85 | DPP4 (0.44) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL6171477 | 0.85 | DPP4 (0.44) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7177541 | 0.83 | DPP4 (0.44) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7177557 | 0.83 | DPP4 (0.59) | DPP4DPP8DPP9DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254113-A1 | N-SUBSTITUTED 2-CYANOPYROLES AND -PYRROLINES WHICH ARE INHIBITORS OF THE ENZYME DPP-IV | NOVO NORDISK A/S (DK) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055105-A1 | N-SUBSTITUTED 2-CYANOPYROLES AND -PYRROLINES WHICH ARE INHIBITORS OF THE ENZYME DPP-IV | NOVO NORDISK A/S (DK) | 2001-08-02 | — | — | WO | disclosed |