Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836252 | 0.89 | ATM (0.43) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL7397628 | 0.88 | ATM (0.44) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL8270815 | 0.87 | ATM (0.43) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL9473183 | 0.86 | ATM (0.40) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL9831090 | 0.86 | ATM (0.40) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL7584316 | 0.86 | ATM (0.43) | ATMCTSSCTSLCTSBCTSK | |
| SCHEMBL7432732 | 0.86 | ATM (0.46) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL9005035 | 0.86 | ATM (0.46) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL6312228 | 0.86 | ATM (0.46) | ATMSCN9ACTSSCTSLCTSB | |
| SCHEMBL7443701 | 0.86 | ATM (0.46) | ATMSCN9ACTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733882-A | Retroviral protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0602069-A4 | RETROVIRAL PROTEASE INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0602069-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-06-22 | — | — | EP | disclosed |
| WO-1993002057-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-04 | — | — | WO | disclosed |