Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL7415840 | 0.97 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7415121 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7012337 | 0.88 | MAPT (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| Ethylene SCHEMBL7413517 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7407879 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7010374 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7412813 | 0.85 | TRPV1 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| Ethylene SCHEMBL7411102 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| Ethylene SCHEMBL7414666 | 0.83 | TRPV1 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL16959264 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |