Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359519 | 0.86 | PDE5A (0.60) | PDE5A | |
| SCHEMBL14599798 | 0.81 | PDE5A (0.62) | PDE5AMEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL7685541 | 0.80 | MEN1 (0.51) | PDE5AMEN1MAPTKMT2A | |
| SCHEMBL7685549 | 0.80 | MEN1 (0.51) | PDE5AMEN1MAPTKMT2A | |
| SCHEMBL7360231 | 0.77 | ABCG2 (0.51) | PDE5A | |
| SCHEMBL1921236 | 0.76 | PDE5A (0.77) | PDE5AMEN1KMT2A | |
| SCHEMBL1326406 | 0.76 | PDE5A (0.77) | PDE5AMEN1KMT2A | |
| SCHEMBL1326404 | 0.76 | PDE5A (0.77) | PDE5AMEN1KMT2A | |
| SCHEMBL7441972 | 0.76 | PDE5A (0.77) | PDE5AMEN1KMT2A | |
| SCHEMBL12194947 | 0.74 | PDE5A (0.65) | PDE5AMEN1MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740668-A1 | TETRACYCLIC DERIVATIVES, PROCESS OF PREPARATION AND USE | LABORATORIES GLAXO WELLCOME S.A. (FR) | 1996-11-06 | — | — | EP | claimed |
| WO-1995019978-A1 | TETRACYCLIC DERIVATIVES, PROCESS OF PREPARATION AND USE | LABORATOIRES GLAXO WELLCOME S.A. (FR) | 1995-07-27 | — | — | WO | claimed |
| WO-1999059584-A1 | COMBINATION OF PHENTOLAMINE AND CYCLIC GMP PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | SCHERING CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |