Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742573 | 0.88 | GRIN2B (0.49) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL742005 | 0.86 | GRIN2B (0.52) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL742047 | 0.85 | GRIN2B (0.57) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL741819 | 0.85 | POLB (0.49) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL740091 | 0.85 | HTR2B (0.56) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL740469 | 0.85 | KDM4E (0.55) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL740090 | 0.85 | HTR2B (0.56) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL739171 | 0.84 | POLB (0.52) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL741429 | 0.82 | POLB (0.49) | KDM4EMAPK1POLBCYP1A2CYP3A4 | |
| SCHEMBL741414 | 0.82 | DPP4 (0.50) | KDM4EMAPK1POLBCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |