Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7417188 | 0.99 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6546409 | 0.89 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7422908 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| Hydrochloric Acid SCHEMBL6546480 | 0.88 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7534256 | 0.86 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7419811 | 0.85 | PDE4A (0.93) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6547157 | 0.85 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DLMNA | |
| Hydrochloric Acid SCHEMBL7419096 | 0.84 | PDE4A (0.92) | PDE4APDE4BPDE4CPDE4DLMNA | |
| Hydrochloric Acid SCHEMBL6545993 | 0.84 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7426520 | 0.84 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841927-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-05-20 | — | — | EP | claimed |
| WO-1997004775-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1997-02-13 | — | — | WO | claimed |
| EP-0841927-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004775-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1997-02-13 | — | — | WO | disclosed |