Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 18/20 | 0.73 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6739466 | 0.96 | GRM2 (0.78) | GRM2CYP11B1 | |
| SCHEMBL6727529 | 0.91 | GRM2 (0.69) | GRM2CYP11B1 | |
| SCHEMBL6733821 | 0.85 | GRM2 (0.61) | GRM2CYP11B1MMP1MMP9MMP13 | |
| SCHEMBL6732349 | 0.84 | GRM2 (1.00) | GRM2 | |
| SCHEMBL6735080 | 0.84 | GRM2 (0.80) | GRM2 | |
| SCHEMBL6730666 | 0.84 | GRM2 (0.76) | GRM2CYP11B1 | |
| SCHEMBL6731475 | 0.84 | GRM2 (0.79) | GRM2 | |
| SCHEMBL6733731 | 0.83 | GRM2 (0.84) | GRM2MMP9 | |
| SCHEMBL6732511 | 0.83 | GRM2 (0.72) | GRM2 | |
| SCHEMBL6731862 | 0.82 | GRM2 (0.78) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | claimed |
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |