Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985912 | 0.91 | HRH3 (0.39) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL6985908 | 0.91 | HRH3 (0.39) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL6985904 | 0.91 | HRH3 (0.39) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL7420077 | 0.80 | HRH3 (0.38) | HRH3DRD2DRD3ALDH1A1MCHR1 | |
| SCHEMBL6985586 | 0.80 | HRH3 (0.45) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL6985380 | 0.80 | HRH3 (0.45) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL6985582 | 0.80 | HRH3 (0.45) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL6984332 | 0.77 | HRH3 (0.43) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL6984339 | 0.77 | HRH3 (0.43) | HRH3DRD2DRD3ALDH1A1CYP3A4 | |
| SCHEMBL6984336 | 0.77 | HRH3 (0.43) | HRH3DRD2DRD3ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934265-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | Du Pont Pharmaceuticals Company (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998006694-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |