Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1136287 | 0.88 | PTGDR2 (0.52) | NPY1RNPY2RPDE4BPDE4DMAPK14 | |
| SCHEMBL4584962 | 0.85 | PDE4A (0.46) | NPY1RNPY2RSLC6A4PDE4BPDE4D | |
| SCHEMBL31535446 | 0.83 | SLC6A4 (0.44) | SLC6A4PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL26984344 | 0.82 | PDE5A (0.47) | NPY1RNPY2RSLC6A4PDE4BPDE4D | |
| SCHEMBL7421048 | 0.81 | PDE4B (0.58) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL7422037 | 0.81 | PDE4B (0.58) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL3635088 | 0.80 | PTGDR2 (0.45) | NPY1RNPY2RPDE4BPDE4DMAPK14 | |
| SCHEMBL7415351 | 0.79 | PDE4B (0.50) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL5703741 | 0.79 | NPY1R (0.46) | NPY1RNPY2RPDE4BPDE4DMAPK14 | |
| SCHEMBL20563399 | 0.79 | NR4A2 (0.48) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |