Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE1A | P54750 | 1/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924574 | 0.86 | PDE5A (0.72) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7491208 | 0.83 | PDE5A (0.71) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3114782 | 0.82 | PDE5A (0.67) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7492759 | 0.81 | PDE5A (0.71) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7496355 | 0.80 | PDE5A (0.70) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7420304 | 0.80 | PDE5A (0.68) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7416234 | 0.79 | PDE4A (0.54) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7471242 | 0.78 | PDE4A (0.77) | PDE5AMEN1KMT2AALDH1A1PDE4A | |
| SCHEMBL8539200 | 0.77 | PDE5A (0.49) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8543991 | 0.77 | PDE5A (0.52) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707998-A | CYCLIC-GMP PHOSPHODIESTERASE INHIBITORS, TREATING CARDIOVASCULAR DISORDERS AND ASTHMA | EISAI CO., LTD. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0691967-A1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | Eisai Co., Ltd. (JP) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022855-A1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | EISAI CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |