Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.56 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728834 | 0.76 | TLK2 (0.61) | KDRGSK3BALKTLK2NPC1 | |
| SCHEMBL6001442 | 0.76 | GSK3B (0.51) | KDRGSK3BALKTLK2NPC1 | |
| SCHEMBL578229 | 0.76 | CDK5 (0.58) | KDRGSK3BALKTLK2MAPT | |
| SCHEMBL5728833 | 0.76 | TLK2 (0.61) | KDRGSK3BALKTLK2NPC1 | |
| SCHEMBL578228 | 0.76 | CDK5 (0.58) | KDRGSK3BALKTLK2MAPT | |
| SCHEMBL6001444 | 0.76 | GSK3B (0.51) | KDRGSK3BALKTLK2NPC1 | |
| SCHEMBL5475086 | 0.75 | KDR (1.00) | KDRGSK3BALKNPC1KMT2A | |
| SCHEMBL5475085 | 0.75 | KDR (1.00) | KDRGSK3BALKNPC1KMT2A | |
| SCHEMBL6000975 | 0.74 | TLK2 (0.62) | KDRGSK3BALKTLK2NPC1 | |
| SCHEMBL6000971 | 0.74 | TLK2 (0.62) | KDRGSK3BALKTLK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883116-A | ANTITUMOR AGENTS AND ENZYME INHIBITORS | SUGEN, INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |