Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.83 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.83 |
| ▸ | PDE1A | P54750 | 1/20 | 0.64 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827710 | 0.87 | PDE5A (0.77) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6305175 | 0.84 | PDE5A (0.72) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6312725 | 0.83 | PDE5A (0.71) | PDE5APDE3BPDE3A | |
| SCHEMBL5827623 | 0.83 | PDE5A (0.73) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5827328 | 0.82 | PDE5A (0.89) | PDE5A | |
| SCHEMBL5827646 | 0.82 | PDE5A (0.69) | PDE5APDE3BPDE3A | |
| SCHEMBL5827510 | 0.82 | PDE5A (0.69) | PDE5APDE3BPDE3A | |
| SCHEMBL5827741 | 0.82 | PDE5A (0.88) | PDE5APDE3BPDE3A | |
| SCHEMBL6308305 | 0.82 | PDE5A (0.69) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6313061 | 0.82 | PDE5A (0.69) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062905-A1 | 8-PHENYLXANTHINE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 1999-12-09 | — | — | WO | disclosed |