Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | TP53 | P04637 | 6/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742321 | 1.00 | MAPT (0.42) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL763295 | 0.93 | TP53 (0.44) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL741578 | 0.93 | KCNH2 (0.45) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL741579 | 0.93 | KCNH2 (0.45) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL741564 | 0.91 | MAPT (0.41) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL741563 | 0.91 | MAPT (0.41) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL741762 | 0.90 | MAPT (0.43) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL741761 | 0.90 | MAPT (0.43) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL740915 | 0.89 | MAPT (0.39) | MAPTTP53KCNH2HRH1CYP2D6 | |
| SCHEMBL740916 | 0.89 | MAPT (0.39) | MAPTTP53KCNH2HRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |