Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.72 |
| ▸ | PDE4A | P27815 | 4/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418798 | 0.87 | PDE4A (0.69) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7421971 | 0.83 | PDE4A (0.81) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7414203 | 0.82 | PDE4A (0.80) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7420827 | 0.82 | PDE4A (0.72) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7423899 | 0.81 | PDE4A (0.71) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7420440 | 0.81 | PDE4A (0.77) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7420647 | 0.81 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7415233 | 0.79 | PDE4A (0.70) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL7417324 | 0.79 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CLMNA | |
| SCHEMBL4176914 | 0.78 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |